A simple, sensitive, reproducible stability indicating UV Spectrophotometric method has been developed for the estimation of Glimepiride in bulk and its various marketed brands of tablets (B1, B2, B3, B4, and B5). Methanol was used as a solvent and 228 nm was selected as maximum wavelength for absorption. Beer’s law was obeyed in the concentration range of 2.5-15 g/ml with correlation coefficient r = 0.9993.The bulk drug and marketed tablet brands (B1, B2, B3, B4 and B5) of glimepiride were subjected to various stress conditions like acid hydrolysis, base hydrolysis, oxidation, photolysis and thermal degradation. Results of the analysis were validated as per ICH guidelines. This method can be used for the routine and quality control analysis of glimepiride in bulk and various pharmaceutical formulations.
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